From 30th Street Train Station
- Walk towards the corridor leading to Septa Regional Rail Lines
- Continue to the end of the corridor and take escalator up to Cira Centre bridge
- Cross over the bridge and take escalator down to Cira Centre Lobby
From Philadelphia International Airport
- Take PA-291 West
- Follow to I-76 West
- Take I-76 West to Exit 345 (30th Street Station)
- Continue straight on Schuylkill Avenue (PA-3 W)
- Bear left as Schuylkill Avenue becomes Arch Street (PA-3 W)
- Cira Centre is on right-hand side
From Center City Philadelphia
- Take JFK Boulevard (PA-3 West)
- Right turn onto Schuylkill Avenue (PA-3 W)
- Bear left as Schuylkill Avenue becomes Arch Street (PA-3 W)
- Cira Centre is on right-hand side
From New Jersey and Points North
- Take the New Jersey Turnpike to Exit 4 (NJ-73)
- Take NJ-73 West to NJ-38 West
- Take NJ-38 West to US-30 West
- Continue on I-676 over the Ben Franklin Bridge to I-76 East
- Exit at 30th Street Station
From Points North (PA)
- Take I-476 South (NE Extension) to Mid-County Interchange (Exit 20)
- Continue on I-476 South (Blue Route) to I-76 East (Exit 16)
- Take I-76 East to Exit 345 (30th Street Station)
From Points West
- Take I-76 (PA Turnpike) to Valley Forge Interchange (Exit 326)
- Continue on I-76 East to Exit 345 (30th Street Station)
From the Northeast
- Take I-95 South to I-676 West (Exit 22)
- Take I-676 West to I-76 East
- Exit at 30th Street Station
From Points South
- Take I-95 North into Pennsylvania
- Take Exit 13 to PA-291 West
- Follow to I-76 West
- Take I-76 West to Exit 345 (30th Street Station)
- Continue straight on Schuylkill Avenue (PA-3 W)
- Bear left as Schuylkill Avenue becomes Arch Street (PA-3 W)
- Cira Centre is on right-hand side
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